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KMID : 0363320030240020260
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 2 p.260 ~ p.268
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Effects of GwakHyangJungGiSan on the Arterial Contraction in Rabbit
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Koo Chang-Mo
Sun Jung-Ki
Kim Ho-Hyun
Nam Chang-Gyu
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Abstract
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Object : This study was undertaken to define the mechanism of GwakHyangJungGiSan-induced relaxation in rabbit common carotid artery contracted by agonists.
Method : In order to investigate the effect of GwakHyangJungGiSan on rabbit’s contracted vascular ring detached from common carotid artery, vascular ring intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of GwakHyangJungGiSan-induced relaxation, GwakHyangJungGiSan extract was infused into contracted vascular ring which had been pretreated by pretreatment of indomethacin(IM), tetraethylammonium chloride(TEA), N{omega}-nitro-L-arginine(L-NNA).
Result : GwakHyangJungGiSan blocks an inflow of Ca{2+} and relaxes vascular ring by the action of Nitric oxide from endothelium. Consequently when GwakHyangJungGiSan is prescribed, a rise in blood pressure by the resistance of peripheral vessel may be controlled to some extent and so it is anticipated that hypertension, a disorder of blood flow from the vascular contraction and vascular disease will be treated well.
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KEYWORD
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GwakHyangJungGiSan, endothelium, hypertension, Nitric oxide
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